Custom Assay Development

You’ve Discovered Your Biomarkers Of Interest. Now What?

After identifying your targets of interest—through WBL services or other methods—our scientists collaborate with you to develop customized targeting solutions optimized for your project’s goals.

 [ Biomarker Discovery ]

WBL Discovery Assays

 [ Targeted Sequencing ]

Assay Development

 [ Deployment ]

RUO, GCP, Clinical Processing

The Development Process

After identifying your targets of interest—through WBL services or other methods—our scientists collaborate with you to develop customized targeting solutions optimized for your project’s goals.

Define Your Focus

Meet with our team to explore your therapeutic area of interest, establish clear objectives, and determine the optimal approach for your desired endpoints.

Identify Your Targets:

Leverage our biomarker discovery services to identify genes, regions, or other genomic features critical to your project.

Target Specific Regions

Utilize hybridization-based enrichment with optimized oligonucleotide probes or bioinformatic targeting to analyze specific regions of interest.

Optimize and Validate

Meet with our team to explore your therapeutic area of interest, establish clear objectives, and determine the optimal approach for your desired endpoints.

[Solution 01]

Custom Bioinformatic Panels For Broad Targeting

WBL offers custom bioinformatic solutions to balance breadth, precision, and efficiency for genomic and methylation panels. Pairing biomarker discovery services with custom bioinformatic pipelines to target regions of interest, WBL’s approach reduces noise and redundancy, delivering high-quality results for methylation and native DNA studies at any scale.

Demonstrating Precision and Sensitivity

Figure 2A. Quantitative Identification of Tissue-Specific Methylation with dMS. Correlations between predicted and actual fractions of Tissue 1-derived DNA show high accuracy with 2,000 randomly selected reads, demonstrating the precision of dMS

Demonstrating Precision and Sensitivity

Figure 2B. Sensitive Detection of Low-Concentration DNA with dMS. dMS achieves accurate detection of Tissue 1-specific DNA at low concentrations, with high correlation (R² = 0.997) even with fewer than 100 reads per dilution.

Overcoming Challenges in Tissue-Specific Methylation Profiling

Identifying DNA’s cell or tissue of origin through methylation analysis has significant clinical applications, but its use in diagnostics has been limited by bisulfite sequencing biases and restricted target coverage. WBL’s dMS enables precise tissue-of-origin determination by detecting complex tissue-specific methylation signatures.

DNA from Tissue 1 and Tissue 2 was sequenced with dWMS. Bioinformatic targeting of 8,457 Tissue 1-specific regions allowed accurate identification (Figure 2A, 2B).

Why Choose Wasatch BioLabs?

From exploratory research to targeted analyses, Wasatch BioLabs empowers precision analysis with unbiased sequencing solutions. Leveraging proprietary technologies like dTMS, tailored workflows, and expert bioinformatics support, we deliver actionable insights to advance your research.

Proprietary, Flexible Solutions

[Service]

Harness advanced tools like dTMS to develop targeted panels, analyze complex variants, and detect epigenetic modifications with scalable workflows for clinical applications.

Bioinformatic Expertise

[Service]

Enhance your data with custom bioinformatics solutions, using tailored workflows and advanced analysis to generate impactful, publication-ready insights.

One-On-One Collaboration

[Service]

Work with native-read sequencing experts with decades of experience in genomics, epigenomics, and bioinformatics to guide your project from discovery to clinical success.

Specialized offerings in our next-generation Biolab

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