Biomarker Discovery

Powered By Nessi-Seq ¬

Understanding Biomarkers

Biomarkers are measurable indicators of a biological state or condition, found in blood, body fluids, and tissues. They provide crucial insights into health status and the presence of disease, empowering healthcare providers to make accurate assessments and informed treatment decisions.

The Role of Biomarkers in Clinical Medicine

The Power of Genomics in Biomarker Discovery:

Genetic and epigenetic sequencing are pivotal in biomarker discovery, offering unparalleled accuracy, throughput, and adaptability for both research and clinical applications. These tools are at the forefront of understanding complex diseases, driving the future of healthcare through precision medicine.

NESSI-Seq Service Details ¬

At Wasatch BioLabs, we specialize in discovering and validating biomarkers that reflect true biological signals. Our services include comprehensive whole-genome approaches and targeted solutions, providing researchers and clinicians with accurate, high-throughput tools positioned to revolutionize diagnostics and patient care.

Unlike standard NGS solutions, WBL’s proprietary NESSI-Seq platform sequences native DNA, eliminating amplification biases, batch effects, and DNA damage from chemical treatments like sodium bisulfite. Leveraging a proprietary library preparation protocol that enhances sensitivity, specificity, and data quality, and Nanopore sequencing, NESSI-Seq technology excels with challenging biological samples like highly fragmented cfDNA and DNA extracted from formalin-fixed tissues. It preserves methylation data across all 27 million CpG sites, and utilizes long-read sequencing for detailed structural variant analysis, offering unparalleled insights for complex genomic and epigenomic studies. 

Whole Genome Sequencing: Whole Genome Sequencing provides comprehensive, long-read coverage of the entire genome, capturing both small and large genetic and epigenetic variations. This approach is ideal for generating high-resolution data on structural variants, SNPs, and other genomic features, making it a powerful tool for research and clinical applications.
Cell-Free Whole Genome Methylation Sequencing(cfWGMS): cfDNA Whole Genome Sequencing provides comprehensive coverage of cell-free DNA, enabling the identification of novel genetic and epigenetic biomarkers across the genome. This service is ideal for advancing biomarker discovery in areas such as oncology, prenatal screening, and disease monitoring, supporting the development of precision diagnostics and therapies.
Low-pass Whole Genome Methylation Sequencing (lpWGMS): gDNA Whole Genome Methylation Sequencing offers a comprehensive alternative to traditional microarrays by capturing methylation data across all 27 million CpG sites. This approach delivers high-resolution insights into sequence, methylation, and hydroxymethylation, making it ideal for complex genomic studies and biomarker discovery.