Direct RNA

Full-Length Native Transcript Sequencing

Explore isoform-level resolution of the transcriptome with WBL’s Direct RNA Sequencing service. Leveraging Oxford Nanopore Technologies (ONT) Direct RNA Sequencing, WBL’s service enables the direct sequencing of full-length, native RNA transcripts without reverse transcription or amplification biases.

Direct RNA Sequencing allows researchers to sequence the transcriptome and visualize native epigenetic modifications, offering researchers and clinical service providers richer transcriptome data with unprecedented insights for multi-omics studies.

The Power of Long read sequencing

Capture the full complexity of RNA molecules in their native state. ONT’s long-reads enable identification of full-length transcripts across diverse species, the resolution of highly repetitive and other complex regions, and the direct detection of post-transcriptional modifications.

Explore the advantages of WBL’s Long-Read Direct RNA Sequencing compared to cDNA and short-read RNA sequencing methods:

cDNA

Short Read RNA

ONT Direct RNA

RNA Sequencing

Small Nucleotide Variants

Methylation & Hydroxy Methylation

Structural Variants

Copy Number Variation

Repetitive Regions

Haplotype

Splice Variants

Fusion Transcripts

Direct RNA Sequencing:
Applications & Use Cases

WBL’s Direct RNA Sequencing offering is ideal for the following types of analyses:

Isoform Analysis

Expression Quantification

Analysis of Methylation

Isoform Co-Quantitative Expression

Fusion Gene Identification

5mC Site Annotation

5mC Site Annotation

Differential Enrichment Analysis

IncRNA Analysis

Transcript Difference Analysis

6mA Site Annotation

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PolyA Analysis

Enrichment Analysis

Enrichment Analysis of Methlation Modifications

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Protein Interaction Network

5mC Differential Analysis

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6mA Differential Analysis

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Accepted RNA Source Samples:

Human
Animal
Plant
Bacteria*
Virus*

Accepted RNA Sources Types:

Poly(A)+ RNA
Total RNA

*WBL currently only accepts DNA and RNA that are extracted from samples that are not classified as infectious. This policy ensures the safety of our laboratory personnel and compliance with regulatory standards. Please ensure that all samples are appropriately treated and certified as non-infectious before submission. If you have any questions about sample preparation or our safety standards, please contact our support team at: support@wasatchbiolabs.com.

More Than a Service Provider — Your Trusted Partner

Accelerate your research with comprehensive nanopore data. With native precision and long reads, Wasatch BioLabs' Nanopore services deliver actionable insights with confidence in every read.

ONT Certified Precision

[Service]

Leverage Oxford Nanopore Technologies-certified services, supported by rigorous quality assurance and control metrics, to achieve reliable data for your research.

Bioinformatic Expertise

[Service]

Enhance your nanopore data with custom bioinformatics solutions, using tailored workflows and advanced analysis to generate impactful, publication-ready insights.

One-On-One Collaboration

[Service]

Work directly with sequencing and bioinformatics experts who provide personalized, end-to-end support, guiding you from project planning to data interpretation.

Specialized offerings in our next-generation Biolab

Explore our other Nanopore Services: